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) Still, even if the occasional patent is rather ridiculous, the patent system is supposed to encourage innovation by setting a limit on how long a company is permitted to maintain a monopoly on its invention Once the patent monopoly ends, rivals can undercut the original manufacturer with identical but lower-priced generic copies as Schering-Plough anticipated with Claritin Supposedly, customers will flock to the cheaper alternative, and the brand-name drug company will then focus on creating another innovative drug It will reap the monopoly profits from that second drug as long as it can, and when that patent expires, turn to the next innovation in its lab And on and on That s the theory, anyway In reality, federal laws have regularly given drug makers more and more ways to extend their patents.

For applications that are intended for a high-powered workstation, we have found that it is usually best to go with a wrapper class that handles the cache automatically But when designing an application for a resourcelimited mobile device where performance is critical and engineering design talent is plentiful, it might be better to manage the cache manually Regardless of whether or not the prepared statement cache is managed manually or automatically, reusing prepared statements is always a good thing and can, in some cases, double or triple the performance of the application..

First came the Hatch-Waxman Act in 1984, which tried to balance the demands of generic and brand-name drugs For the generic companies, it granted bioequivalency, letting them obtain FDA approval if they just showed that the active ingredient in their drug was released and absorbed into the body at about the same rate as the active ingredient in the original Thus, generic companies did not have to repeat all the clinical trials that had been conducted for the first NDA These companies also were allowed to file their applications and get tentative approval in advance, so that they could jump right into the market the day the patent expired In return, the brand-name companies got a patent extension of five years, plus three more years for any secondary usage that was approved and this was crucial 30 months if they challenged a generic.

The first icon shown, IDI_RESOURCE_FILE, is the application s main icon. That is, it is the one that is displayed when the user creates a shortcut to the application. Win32 applications main icons are 32 by 32 pixels and may use the full range of system colors. By contrast, Windows CE icons must be no larger than 16 by 16 pixels, and must be explicitly loaded by the application. If the icon is too large, it won t load. The second icon in the resource file, IDI_SMALL, is used to represent the application in list views (for example, Windows Explorer). This icon is superfluous on the CE side and should be eliminated.

eaving the FDA s drab Rockville headquarters, where the Antigenics executives learned of their clinical hold, it s about a five-minute drive to the modern, white, six-floor office building that Phil Noguchi s staff in the FDA s Center for Biologics Evaluation and Research (known as CBER) share with an accounting firm, an insurance company, and several other private businesses. Right next door, overlooking a development of brick townhouses, another medium-size leased office building houses some employees from a different arm of the FDA, the Center for Drug Evaluation and Research (CDER). Drive about 20 miles southeast to College Park, Maryland, and you re at the sprawling, brand-new offices of a third FDA branch, the Center for Food Safety and Applied Nutrition (CFSAN). Including its parking lot, the four-story building spreads across an entire block, centered around a sunny, book-lined atrium. Or, from Rockville, take the Metro train three stops toward Washington, D.C., to the Bethesda, Maryland, campus of the National Institutes of Health (NIH). The main offices of CBER are in a five-story, red-brick building there, tucked just under a small hill. Elsewhere in Rockville, the FDA s Center for Veterinary Medicine (CVM) is almost hidden in a nondescript corporate park, without even a sign on the outside of its low-slung brick facility. The Center for Devices and Radiological Health (CDRH) sits in yet another standard-issue corporate park in

Subsequently, to conform to the rules of the General Agreement on Tariffs and Trade and the World Trade Organization, the United States in 1994 changed the term of its patents to 20 years from the date of application, versus the previous limit of 17 years from the date it was granted which, depending on the circumstances, might mean a longer effective monopoly in.